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目的观察多烯磷脂酰胆碱对非酒精性脂肪肝病的疗效及安全性。方法 84例非酒精性脂肪肝病患者,随机分为治疗组与对照组,各42例,治疗组用多烯磷脂酰胆碱治疗,对照组用甘利欣治疗,疗程均为3个月。分别观察治疗前、治疗4周后及治疗结束后血清总胆固醇(TC)、甘油三酯(TG)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)及肝脏B超变化。结果治疗组临床症状、肝功能、血脂、B超检查结果改善均优于对照组。治疗组有效率85.71%(36/42),对照组有效率66.67%(28/42),两组疗效比较差异有统计学意义(P<0.05)。结论多烯磷脂酰胆碱治疗非酒精性脂肪肝具有良好的效果,值得临床应用。
Objective To observe the efficacy and safety of polyene phosphatidylcholine on non-alcoholic fatty liver disease. Methods Eighty-four patients with non-alcoholic fatty liver disease were randomly divided into treatment group and control group, with 42 cases in each group. The treatment group was treated with polyene phosphatidylcholine and the control group was treated with glycopyrite for 3 months. The changes of serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and liver B after 4 weeks of treatment and after treatment were observed respectively. Super change. Results The improvement of clinical symptoms, liver function, blood lipid and B-ultrasound in the treatment group were better than those in the control group. The effective rate was 85.71% (36/42) in the treatment group and 66.67% (28/42) in the control group, with significant difference between the two groups (P <0.05). Conclusion Polyene phosphatidylcholine treatment of non-alcoholic fatty liver has good results, it is worth clinical application.