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作者报道用Cyclosporin A治疗活动性克隆氏病的临床经验。 7例克隆氏病患者平均病程为8±7年,5例因此病曾至少做一次手术治疗。2例有小肠复杂性瘘管。停用类固醇和柳氮磺胺吡啶后,接受Cyclosporin A治疗,开始剂量为8mg/kg/d,每2周调整用量,以维持血浆Cyclosporin A浓度达200ng/ml。4例病人治疗16周。1例23周和1例30周。1例服用Cyclosporin A后不久发生恶心、腹痛和腹泻而停药。 Cyclosporin A治疗前,病人的克隆氏
The authors report the clinical experience of Cyclosporin A in the treatment of active Crohn’s disease. Seven patients with Crohn’s disease average duration of 8 ± 7 years, 5 patients had at least one surgical treatment. 2 cases of intestinal complexity of fistula. After discontinuation of steroids and sulfasalazine, Cyclosporin A treatment was started at a dose of 8 mg / kg / d every two weeks to maintain plasma Cyclosporin A concentration of 200 ng / ml. Four patients were treated for 16 weeks. 1 case of 23 weeks and 1 case of 30 weeks. One patient discontinued taking nausea, abdominal pain and diarrhea shortly after taking Cyclosporin A. Clones of patients before Cyclosporin A treatment