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目的：探讨 Ｐ５３基因对Ⅳ型胶原纤维（ ＣｏⅣ）的影响及临床诊断意义。方法：用免疫组化方法观察 ＣｏⅣ和 Ｐ５３蛋白在１９ 例喉癌（ Ｃ Ａ）和３４ 例不典型增生（ Ｄ Ｓ）中的表达。结果： ＣｏⅣ表达呈线型， Ｐ５３ 蛋白表达呈核型，两者在 Ｃ Ａ 中呈负相关性。在 Ｄ Ｓ中 ＣｏⅣ表达率为 ４４％ ， Ｐ５３蛋白表达率为５８％ 。结论： ＣｏⅣ和 Ｐ５３蛋白在喉癌中均有表达，当 Ｐ５３蛋白超表达时， ＣｏⅣ的量明显减少； ＣｏⅣ免疫组化可以做为 Ｐ５３蛋白在 Ｄ Ｓ诊断中的辅助指标。
Objective: To investigate the effect of P53 gene on type Ⅳ collagen fibers (Co Ⅳ) and its clinical significance. Methods: The expressions of CoⅣ and P53 in 19 cases of laryngeal carcinoma (C A) and 34 cases of atypical hyperplasia (D S) were observed by immunohistochemistry. Results: The expression of Co Ⅳ was linear and the expression of P53 protein was karyotype. There was a negative correlation between them in C A. In D S Co Ⅳ expression rate of 44%, P53 protein expression rate of 58%. Conclusion: Co Ⅳ and P53 protein are expressed in laryngeal carcinoma. When P53 protein is overexpressed, the amount of Co Ⅳ is significantly reduced. Co Ⅳ immunohistochemistry can be used as an auxiliary index in the diagnosis of D S.