目的　了解肺隐球菌病临床特点及治疗方法。方法　回顾分析北京协和医院 1 986～2 0 0 1年隐球菌病临床资料 ,并对肺隐球菌病例的性别、发病年龄、基础病、免疫状况、呼吸道症状、确诊方法、影像学资料、抗真菌药物及疗程、疗效及随诊经过进行分析。结果　隐球菌病共 30例 ,其中肺隐球菌病 7例 ,1例合并隐球菌脑膜炎 ,而隐球菌脑膜炎 1 8例 ;肺隐球菌病 :男 /女 =4/ 3 ,平均年龄41 8岁 ;均可排除人类免疫缺陷病毒 (HIV)感染 ,6例免疫功能正常 ,1例有乙状结肠癌病史 ,并曾接受泼尼松治疗 ;均在起病后 1～ 2个月通过病理学及细菌学检查明确诊断 ;均接受了不同的抗真菌药物治疗 ,预后良好。结论　 (1 )临床诊断的肺隐球菌病远少于隐球菌脑膜炎 ;(2 )痰隐球菌培养、手术标本显微镜检粘卡染色、高碘酸希夫反应、六胺银染色是确诊依据 ;(3)免疫功能正常的肺隐球菌病患者预后良好 ;(4)治疗肺隐球菌病的药物及疗程值得进一步研究 Objective To understand the clinical features and treatment of pulmonary cryptococcosis. Methods The clinical data of Cryptococcosis from 1986 to 2001 in Peking Union Medical College Hospital were retrospectively analyzed. The clinical features, such as gender, age at onset, underlying diseases, immune status, respiratory symptoms, diagnosis methods, imaging data, antifungal Drugs and treatment, efficacy and follow-up after the analysis. Results Cryptococcal disease in 30 cases, including pulmonary cryptococcosis in 7 cases, 1 case of cryptococcal meningitis, and cryptococcal meningitis 18; pulmonary cryptococcosis: male / female = 4/3, mean age 41 8 Year-old; can eliminate the human immunodeficiency virus (HIV) infection, 6 cases of normal immune function, 1 case of history of sigmoid colon cancer, and had received prednisone treatment; were 1 to 2 months after onset by pathology and bacteria A clear diagnosis of laboratory tests; have received different antifungal agents, the prognosis is good. Conclusions (1) Clinically diagnosed pulmonary cryptococcosis is far less than that of cryptococcal meningitis; (2) Cryptococcus neoformans culture, microscopic examination of surgical specimens with card sticking, periodic acid Schiff reaction, hexamine silver staining are the basis of diagnosis; (3) patients with normal immune function of pulmonary cryptococcosis have a good prognosis; (4) drugs and treatment of pulmonary cryptococcosis deserves further study