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目的探讨超敏C-反应蛋白检测在新生儿败血症早期诊断中的应用价值。方法蚌埠市第二人民医院诊治的新生儿败血症患儿在采血进行病原菌培养时,对其进行血清超敏C-反应蛋白定量分析。选择54例新生儿血培养结果阳性患儿做为治疗前组,新生儿败血症患儿复查血培养时,再次测定血清超敏C-反应蛋白,血培养转为阴性时做为治疗后组,另选取无感染征象新生儿42例为对照组。观察比较各组患儿血清超敏C-反应蛋白的变化。结果新生儿败血症患儿超敏C-反应蛋白阳性率治疗前为90.7%(49/54),治疗后为25.9%(14/54),对照组为14.3%(6/42)。各组超敏C-反应蛋白间比较差异有统计学意义(P<0.05)。结论血清超敏C-反应蛋白测定有助于新生儿败血症的临床早期诊断。
Objective To investigate the value of high sensitivity C-reactive protein in the early diagnosis of neonatal sepsis. Methods Children with neonatal sepsis diagnosed and treated in Second People’s Hospital of Bengbu City were tested for serum high-sensitivity C-reactive protein when blood was collected for pathogen culture. Select 54 cases of neonatal blood culture positive children as the treatment group, neonatal sepsis in children under review of blood culture, re-determination of serum high-sensitivity C-reactive protein, blood culture turned negative as the treatment group, and the other Twenty-four neonates without infection were selected as the control group. The changes of serum high-sensitivity C-reactive protein in children were observed and compared. Results The positive rate of hypersensitivity C-reactive protein in neonates with sepsis was 90.7% (49/54) before treatment, 25.9% (14/54) after treatment and 14.3% (6/42) in control group. The difference between the groups of high-sensitivity C-reactive protein was statistically significant (P <0.05). Conclusion Serum high sensitivity C-reactive protein is helpful for the early clinical diagnosis of neonatal sepsis.