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[目的]探讨基质金属蛋白酶(MMP)、血管内皮生长因子(VEGF)在原发肾细胞癌组织中的表达及与其临床特征和预后的相关性.[方法]选取2009年1月至2014年6月本院收治的72例肾细胞癌患者的临床资料,采用免疫组化染色观察肾癌组织中MMP-2、MMP-9和VEGF的表达情况,并采用非条件Logistic回归分析 MMP-2、MMP-9、VEGF表达与肾细胞癌患者临床特征和预后的相关性.[结果]肾细胞癌组织中MMP-2、MMP- 9、VEGF表达水平均随着TNM分期升高逐渐升高,各分期之间比较差异均具有统计学意义(P <0.05).本组3年存活50例(存活组),死亡22例(死亡组);存活组TNM分期I + Ⅱ期患者所占比例高于死亡组(P <0.05);死亡组MMP2、MMP-9、VEGF表达水平均高于存活组,差异均具有统计学意义(P <0.05).TNM分期、MMP- 2、MMP-9、VEGF是影响肾细胞癌患者预后的主要危险因素(OR值分别为1,326、1,559、1.734、1.846,P <0.05).[结论]肾细胞癌组织中MMP-2、MMP-9、VEGF表达与TNM分期相关,并随着TNM分期升高而升高,MMP-2、 MMP-9、VEGF是影响肾细胞癌患者预后的危险因素.“,”[Objective]To investigate the expression of MMP and VEGF in primary renal cell carcinoma and its relationship with clinical features and prognosis of renal cell carcinoma. [Methods]A total of 72 cases of renal cell carcinoma confirmed by pathology in our hospital from January 2009 to June 2014 were selected,immunohis- tochemical staining was used to observe the expression of MMP-2, MMP-9 and VEGF in renal cell carcinoma, and the relationship between MMP-2,MMP-9 and VEGF expression and renal cell carcinoma was studied by unconditional Logistic regression.[Results]The expression of MMP-2, MMP-9, VEGF in renal cell carcinoma (RCC) increased gradually with the increase of TNM stage, and the difference was statistically significant among the different stages (P <0.05). In this group, 50 cases survived (the survival group), 22 cases died (the death group), the proportion of TNM stage I - Ⅱ patients in the survival group was higher than that in death group (P <0.05). The expression of MMP2,MMP-9,VEGF in the dead group was significantly higher than that in the survival group (P <0.05). In TNM stage, MMP-2,MMP-9,VEGF was the main risk factor for the prognosis of renal cell carcinoma (OR=1.326,1.559,1.734,1.846, P <0.05).[Conclusion]The expression of MMP-2,MMP-9, VEGF in renal cell carcinoma is correlated with TNM stage and increases with the increase of TNM stage. MMP- 2,MMP-9,VEGF are risk factors for the prognosis of renal cell carcinoma.