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[目的]研究原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)及自身免疫性肝炎(autoimmune hepatitis,AIH)的病理特点,寻找有效的病理诊断指标。[方法]从2006~2012年昆明医科大学病理教研室肝穿活检病例中筛选病理诊断PBC 47例[其中血清检测抗线粒体抗M_2亚型(AMA-M_2)阳性30例、AMA-M_2阴性17例],自身免疫性肝炎(autoimmune hepatitis,AIH)20例。采用免疫组化方法检测所有病例肝组织内CD11C的表达情况。[结果]PBC AMA-M_2阳性组与PBC AMA-M_2阴性组CD11C阳性单位相比差异无统计学意义(P>0.05),PBC AMA-M_2阳性组、PBC AMA-M_2阴性组分别与AIH组CD11C阳性单位相比,均差异有统计学意义(P<0.05)。[结论]CD11C主要表达于肝脏门管区肉芽肿内,有助于PBC的诊断。
[Objective] To study the pathological features of primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) in order to find an effective pathological diagnosis index. [Methods] Forty-seven patients with pathologically diagnosed PBC were screened for liver biopsy from the Department of Pathology, Kunming Medical University from 2006 to 2012. Among them, 30 were positive for anti-mitochondrial anti-M_2 (AMA-M_2) and 17 were negative for AMA-M_2, , Autoimmune hepatitis (AIH) 20 cases. Immunohistochemistry was used to detect the expression of CD11C in all cases. [Results] There was no significant difference in CD11C positive units between PBC AMA-M 2 positive group and PBC AMA-M 2 negative group (P> 0.05), PBC AMA-M 2 positive group and PBC AMA-M 2 negative group were respectively associated with AIH group CD11C Positive units, the differences were statistically significant (P <0.05). [Conclusion] CD11C is mainly expressed in the granuloma of the hepatic portal area, which is helpful for the diagnosis of PBC.