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目的 :评价血清SIL - 2R ,IL - 6 ,IL - 10和CL -Ⅳ对早期诊断肾移植排斥反应的价值。方法 :检测了 34名肾移植病人及 2 0名正常对照者血清SIL - 2R ,IL - 6 ,IL - 10 ,CL -Ⅳ的水平 ,通过分析特征工作曲线(ROC)评价其对早期诊断肾移植排斥反应的价值。结果 :在肾移植排斥组中 ,SIL - 2R ,IL - 6及IL - 10均显著高于肾功能稳定组及正常对照组 ,而CL -Ⅳ在排斥组及肾功能稳定组间无明显差异 ,但高于正常对照组。通过ROC曲线下面积分析 ,发现IL - 6最为敏感 ,SIL - 2R次之 ,IL - 10与CL -Ⅳ效果较差。结论 :SIL -2R和IL - 6是监测肾移植早期排斥反应的良好指标。
Objective: To evaluate the value of serum SIL - 2R, IL - 6, IL - 10 and CL - Ⅳ in the early diagnosis of renal allograft rejection. Methods: The levels of serum SIL - 2R, IL - 6, IL - 10 and CL - Ⅳ in 34 renal transplant recipients and 20 normal controls were measured. The characteristics of working curves (ROC) Rejection of the value of the reaction. Results: The levels of SIL - 2R, IL - 6 and IL - 10 in renal transplantation rejection group were significantly higher than those in stable renal function group and normal control group, while there was no significant difference in CL - Ⅳ between rejection group and stable renal function group, But higher than the normal control group. The area under ROC curve analysis showed that IL - 6 was the most sensitive, followed by SIL - 2R, while IL - 10 and CL - Ⅳ were less effective. Conclusion: SIL - 2R and IL - 6 are good indicators of renal allograft rejection in early stage.