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本文采用高效液相色谱法，对盐酸洛美沙星颗粒剂在健康人体内的药动学进行了试验研究。10名男性健康志愿者，单剂量口服盐酸洛美沙星颗粒剂各400mg，尔后经时采集静脉血，测定血药浓度，药－时数据经PKBP－N1程序处理，得盐酸洛美沙星的药动学参数为：Lagtime0．058±0．033h，Tmax0．74±0．33h，Cmax4．24±0．78μg／ml，t1／2x0．94±0．82h，t1／2β7．77±1．13h，VC87．02±34．10L，K120．268±0．26，K21 0．863±0．16，K10 0．189±0．076。
In this paper, high performance liquid chromatography was used to study the pharmacokinetics of lomefloxacin hydrochloride granules in healthy volunteers. 10 male healthy volunteers, a single oral dose of lomefloxacin hydrochloride granules 400mg, after the collection of venous blood over time, the determination of plasma concentration, drug-time data by PKBP-N1 program to be pharmacokinetic Lomefloxacin hydrochloride The learning parameters were: Lagtime0.058 ± 0.033h, Tmax0.74 ± 0.33h, Cmax4.24 ± 0.78μg / ml, t1 / 2x0.94 ± 0.82h, t1 / 2β7.77 ± 1.13h, VC87.02 ± 34.10 L, K120.268 ± 0.26, K21 0.863 ± 0.16, K10 0.189 ± 0.076.