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我们采用套式PCR方法回顾性研究了一组接受干扰素治疗的慢性丙型肝炎患者的TTV感染状况,对TTV重叠感染时丙型肝炎肝组织病变及干扰素治疗状况进行分析。研究结果对评价TTV致病性具有一定意义。 1 材料和方法 1.1材料病例及治疗:29例慢性丙型肝炎患者,均为肝功能持续异常超过6mo,血清抗HCV及HCV RNA阳性,乙型肝炎标志阴性。男16例,女13例,平均年龄34.6岁。采用α-2a干扰素300万u,或组合干扰素(CIFN)9μg或15μg,3次·d~(-1)cc,共24wk(5例用药12wk),停药后随访24wk以上。疗效判断标准为,ALT应答:ALT恢复正常;病毒应答:HCV RNA定性检测
We used retrograde nested PCR to retrospectively examine the prevalence of TTV infection in a group of patients with chronic hepatitis C treated with interferon and analyze the pathological changes of hepatitis C liver tissue and the treatment of interferon in patients with TTV overlap infection. The results of the evaluation of pathogenic TTV has some significance. 1 Materials and methods 1.1 Materials and treatment: 29 cases of chronic hepatitis C patients, all with abnormal liver function over 6mo, serum anti-HCV and HCV RNA positive, hepatitis B negative. 16 males and 13 females, with an average age of 34.6 years. Interferon α-2a 3 million u, or combination of interferon (CIFN) 9μg or 15μg, 3 times · d ~ (-1) cc, a total of 24wk (5 cases of medication 12wk), after discontinuation of follow-up more than 24wk. Efficacy criteria, ALT response: ALT returned to normal; virus response: qualitative detection of HCV RNA