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目的:了解心胸外科临床药师参与围手术期预防用抗菌药的情况,对比分析临床药师对临床合理使用抗菌药的干预作用。方法:收集临床药师参与前2008年7～12月手术病历188份,参与后2009年7～12月手术病历210份,分析用药合理性。结果:临床药师参与心胸外科围手术期预防用抗菌药后,其选药、用药时机、用法、剂量、用药方式趋于合理,用药时间大幅缩短。但仍存在选药广谱、用药疗程偏长、剂量偏大、不必要的联合用药等问题。结论:临床药师参与围手术期预防用抗菌药的监督作用仍需加强。
Objective: To understand the clinical pharmacists involved in cardiopulmonary surgery perioperative prophylaxis with antimicrobial agents, comparative analysis of clinical pharmacists on the clinical rational use of antibacterial intervention. Methods: 188 cases of clinical medical records from July to December 2008 were collected before the participation of clinical pharmacists. 210 cases of surgical records from July to December 2009 were collected to analyze the rationality of drugs. Results: After participating in the perioperative prophylaxis with antibacterial agents, cardiothoracic surgeons chose to use drugs, time, usage, dosage and methods of medication to be reasonable and their medication time was shortened significantly. However, there are still some problems such as broad spectrum of drug selection, long course of treatment, large dosage, unnecessary combination therapy and the like. Conclusion: The role of clinical pharmacists in monitoring perioperative prophylactic antibacterials still needs to be strengthened.