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目的:通过观察滋阴方联合美常安治疗2型糖尿病便秘的影响,探讨其改善气阴两虚型2型糖尿病便秘的可能机制。方法:采用控制饮食、糖尿病教育、运动等基础治疗。随机分为观察组和对照组各30例。治疗前后均测定空腹血糖、餐后两小时血糖、糖化血红蛋白,根据患者大便情况,分别给药6-8周后,进行治疗前后症状改善情况、疗效情况及相关血糖指标比较。结果治疗后患者临床疗效明显优于单用美常安组(P<0.05),并且观察组在排便次数及性状方面改善明显优于单独应用西药组(P<0.05),且各组之间比较,差异无统计学意义(P>0.05)。结论:滋阴方对2型糖尿病气阴两虚型便秘疗效显著并对2型糖尿病患者血糖也有一定改善作用。
OBJECTIVE: To explore the possible mechanism of constipation in type 2 diabetic patients with qi and yin deficiency by observing the effect of Ziyin prescription combined with pianan on constipation of type 2 diabetes mellitus. Methods: The control diet, diabetes education, exercise and other basic treatment. Randomly divided into observation group and control group of 30 cases. Fasting blood glucose, fasting blood glucose and glycosylated hemoglobin were measured before and after treatment for two hours. According to the patients’ stool, after 6-8 weeks of treatment, the symptoms were improved, the curative effect and the related blood glucose levels were compared. Results The clinical curative effect of the patients after treatment was obviously better than that of the normal group (P <0.05), and the improvement of defecation times and traits in the observation group was obviously better than that of the Western medicine alone group (P <0.05) The difference was not statistically significant (P> 0.05). Conclusion: Ziyin Formula has obvious curative effect on constipation of qi-yin-deficiency type of type 2 diabetes mellitus and blood glucose of type 2 diabetes mellitus patients.