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目的:观察痹祺胶囊对骨关节炎软骨代谢的作用。方法:以Hulth法复制兔膝骨关节炎模型,对软骨组织行Mankin标准评分,设置空白组、假手术组,观测各组兔血清及尿液的羟脯氨酸含量,并设痹祺胶囊低、中、高浓度组及西药组以了解其疗效。结果:各治疗组间Mankin标准评分水平无差异,痹祺胶囊各剂量组血清、尿羟脯氨酸含量与模型组比较差异均有显著意义(P<0.05)。结论:痹祺胶囊可通过促进骨修复或抑制软骨破坏而减低兔骨关节炎模型体内羟脯氨酸含量,对骨关节炎软骨代谢有明确的改善作用。
Objective: To observe the effect of Biqi capsule on cartilage metabolism of osteoarthritis. Methods: Rabbit knee osteoarthritis model was made by Hulth method. Mankin standard score was applied to cartilage tissue. Blank group and sham operation group were set up to observe the contents of hydroxyproline in serum and urine of rabbits in each group. , Medium and high concentration group and Western medicine group to understand its curative effect. Results: There was no difference in the Mankin standard score among the treatment groups. The contents of serum and urinary hydroxyproline in each dose group were significantly different from those in the model group (P <0.05). Conclusion: Biqi Capsule can reduce the content of hydroxyproline in rabbit model of osteoarthritis by promoting the repair of bone or inhibiting the destruction of cartilage, which can obviously improve the cartilage metabolism of osteoarthritis.