目的:观察氨酚羟考酮片治疗膝关节骨性关节炎引起的中度到重度疼痛的效果。方法:50例伴严重疼痛的膝关节骨性关节炎患者口服氨酚羟考酮片治疗12 d,观察疼痛的缓解程度和不良反应。结果:患者疼痛均有明显缓解,有效率达95.7%,显效率达84.8%,不良反应轻微。结论:氨酚羟考酮片治疗膝关节骨性关节炎引起的严重疼痛安全有效。 Objective: To observe the effect of oxycodone on the moderate to severe pain caused by knee osteoarthritis. Methods: 50 patients with severe pain in patients with knee osteoarthritis were treated with oxycodone for 12 days, and the degree of pain relief and adverse reactions were observed. Results: All the patients had obvious pain relief. The effective rate was 95.7%, the effective rate was 84.8% and the adverse reaction was mild. Conclusion: Oxycodone Tablets are safe and effective in treating severe pain caused by osteoarthritis of knee joint.