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国产亚胺培南／西司他丁的体外抗菌活性研究结果表明，国产亚胺培南／西司他丁与该药的进口产品抗菌谱相同，抗菌活性相近，两药在浓度为８μｇ／ｍｌ时，对１０种共８０９株临床分离菌的抑制率均为９６％，而头孢噻肟为６２％。国产亚胺培南／西司他丁对甲氧西林敏感金葡球菌（ＭＳＳＡ）、耐甲氧西林金葡球菌（ＭＲＳＡ）、表葡球菌、化脓性链球菌、肠球菌的抗菌活性明显优于头孢噻肟；对铜绿假单胞菌的活性明显优于头孢哌酮和头孢噻肟；对大肠杆菌、肺炎克雷伯氏菌、肠杆菌和变形杆菌的抗菌活性与头孢噻肟相近或稍弱。国产亚胺培南／西司他丁对金葡球菌、大肠杆菌和铜绿假单胞菌在浓度为１ＭＩＣ时具有杀菌作用。国产亚胺培南／西司他丁的体外抗菌活性不受ｐＨ影响，稍受接种量、血清浓度的影响，但对铜绿假单胞菌的抗菌活性不受接种量的影响。
The results of in vitro antibacterial activity of domestic imipenem / cilastatin showed that the antibacterial spectrum of domestic imipenem / cilastatin was similar to that of the imported product, and the antibacterial activities were similar. The two drugs were tested at the concentration of 8μg / ml , The inhibitory rates of 10 strains of 809 clinical isolates were 96%, while the cefotaxime was 62%. The antibacterial activity of domestic imipenem / cilastatin against methicillin-resistant Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Streptococcus pyogenes and Enterococcus was significantly better Cefotaxime; Pseudomonas aeruginosa activity was significantly better than cefoperazone and cefotaxime; E. coli, Klebsiella pneumoniae, Enterobacter and Proteus antibacterial activity and cefotaxime similar or slightly weaker . Domestic imipenem / cilastatin against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa at a concentration of 1 MIC have a bactericidal effect. In vitro antibacterial activity of domestic imipenem / cilastatin was not affected by pH, slightly affected by inoculum size and serum concentration, but the antibacterial activity against Pseudomonas aeruginosa was not affected by inoculum size.