矮小症是儿科内分泌常见疾病之一。本文报道有些非生长激素(growth horwone,GH)缺乏的矮小症儿童GH分泌异常应用外源性人生长激素(hGH)有效。方法 45名儿童,其中7例为GH神经分泌功能紊乱矮小症(诊断标准:身长低于正常低限,生长速度≤4cm/年,骨龄落后2年或以上,生长介素-C水平降低,GH24小时分泌图象异常,GH兴奋试验正常即峰值≥10ng/ml);16例GH缺乏矮小症(诊断标准同上,但GH兴奋试验异常,即精氨酸、胰岛素、左旋多巴兴奋试验中有2项或2项以上峰值<10ng/ml);对照组22例(其中9例身材矮小,但 Short stature is one of the common diseases of pediatric endocrine. This article reports that GH dysregulation in some short stature children lacking growth hormones is effective with exogenous human growth hormone (hGH). METHODS: Forty-five children, of whom 7 were short stature of GH neurodevelopmental dysfunction (diagnostic criteria: those with lower than normal limits of height, with a growth rate of ≤ 4 cm / year, with a 2 years or more behind the bone age, with reduced levels of growth hormone, Hour secretion of abnormal images, GH normal test that peak ≥ 10ng / ml); 16 cases of GH deficiency short stature (diagnostic criteria Ibid, but GH abnormalities test that arginine, insulin, levodopa excitability test in 2 Item or two or more peaks <10ng / ml); control group of 22 patients (of which 9 were short stature, but