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为了了解口服拉莫三嗪(LTG)的药动学以及评价拉莫三嗪与其它抗癫痫药物(AED)之间可能产生的相互作用,本文测定血浆和脑脊液(CSF)中LTG及其它AED的浓度。以31例>2岁的难治性全身性癫痫儿童为对象,研究了与三种以上常规抗癫痫药物的相互作
In order to understand the pharmacokinetics of oral lamotrigine (LTG) and to evaluate the possible interactions between lamotrigine and other antiepileptic drugs (AEDs), we examined the effects of LTG and other AEDs in plasma and cerebrospinal fluid (CSF) concentration. A total of 31 children with refractory generalized epilepsy> 2 years old were studied for their interaction with more than three conventional antiepileptic drugs