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前言化学疗法的原则是药物对病原微生物具有很强的杀伤作用,而对人体的作用很少。也就是把具有选择毒性的药物经全身使用治疗感染症。这是现代医学最可靠的治疗手段之一。自从发现磺胺类药物和使用青霉素以来,已过了近半个世纪。在这期间,耐药菌逐渐增加,治疗上也不断遇到种种困难。细菌的耐药性是由突然变异与选择、耐药质粒(R plasm1d)的传递、转导(transduction)等不同的机理产生。质粒上的耐药遗传因子,
Introduction The principle of chemotherapy is that the drug has a strong killing effect on the pathogenic microorganisms and has little effect on the human body. That is to have the selective toxicity of drugs for systemic treatment of infectious diseases. This is one of the most reliable treatments in modern medicine. Nearly half a century has passed since the discovery of sulfonamides and the use of penicillin. During this period, drug-resistant bacteria gradually increased, and treatment continued to encounter various difficulties. Bacterial resistance is caused by various mechanisms such as sudden mutation and selection, transmission of resistant plasmids (R plasm1d) and transduction. Plasmids resistant genetic factors,