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目的:探讨酒精性肝病（ALD）合并2型糖尿病（T2DM）患者的临床特点及危险因素。方法:回顾性分析广西医科大学第一附属医院2015年3月至2020 年3月诊断为 ALD合并T2DM患者70例（研究组）的临床资料，另选取同期收治的ALD患者69例（ALD组）及T2DM 患者69例（T2DM组）为对照，收集三组患者的性别、年龄、体质量指数（BMI）、饮酒习惯等基本情况并采用logistic回归分析ALD合并T2DM的危险因素。结果:研究组每天酒精摄入量、饮酒年数分别为（110.97±79.78）g/d、（25.17±10.05）年，显著高于ALD组的（91.48±64.26）g/d、（21.78±8.91）年（n t=1.699、2.102，均n P<0.05）；研究组代谢综合征（MS）发生率为34.3%（24/70），显著高于 ALD组的15.9%（11/69）（χn 2=6.210，n P<0.05）；研究组天冬氨酸氨基转移酶/丙氨酸氨基转移酶（AST/ALT）、总胆红素 （TBIL） 、γ-谷氨酰转肽酶（GGT）分别为（1.59±0.93）、（64.73±39.90）μmol/L、（522.93±353.66）U/L，均显著高于T2DM组的（1.04±0.53）、（10.37±4.51）μmol/L、（35.73±23.99）U/L（n t=4.280、3.780、5.045，均n P<0.05）；研究组三酰甘油（TG）［（1.69±1.04）mmol/L］显著高于ALD组［（1.28±0.87）mmol/L］（n t=2.523，n P<0.05），研究组凝血酶原时间（PT）［（13.13±2.79）s］、乳酸脱氢酶（LDH）［（226.17±79.93）U/L］显著高于 T2DM组［（10.41±0.84）s、（172.63±39.34）U/L］（n t=7.715、4.969，均n P<0.05）；logistic 多因素回归分析显示，PT、TG、饮酒年数、GGT、饮酒量为导致ALD合并T2DM的主要危险因素（n OR=2.010、3.270、1.230、1.060、1.006，均n P<0.05）。n 结论:ALD合并T2DM患者易存在MS和脂质紊乱，可能加重患者病情；PT、TG、饮酒年数等在ALD合并T2DM的发展中起到重要作用。“,”Objective:To investigate the clinical characteristics and risk factors of alcoholic liver disease (ALD) combined with type 2 diabetes mellitus (T2DM).Methods:The clinical data of 70 patients with ALD combined with T2DM (ALD + T2DM group) who received treatment from March 2015 to March 2020 in the First Affiliated Hospital of Guangxi Medical University were retrospectively analyzed. The clinical data of 69 patients with ALD (ALD group) and 69 patients with T2DM (T2DM group) who concurrently received treatment were also analyzed. Sex, age, body mass index, drinking habits and other basic information in the three groups were collected. The risk factors of ALD combined with T2DM were evaluated by logistic regression analysis.Results:The daily alcohol intake and years of drinking in the ALD + T2DM group were (110.97 ± 79.78) g/d and (25.17 ± 10.05) years, respectively, which were significantly higher than (91.48 ± 64.26) g/d and (21.78 ± 8.91) years respectively in the ALD group (n t = 1.699, 2.102, both n P < 0.05). The incidence of metabolic syndrome in the ALD + T2DM group was 34.3% (24/70), which was significantly higher than 15.9% (11/69) in the ALD group ( n χ2 = 6.210, n P < 0.05). The activity ratio of aspartate aminotransferase/alanine aminotransferase, total bilirubin level, gamma glutamyl transpeptidase activity in the ALD + T2DM group were 1.59 ± 0.93, (64.73 ± 39.90) μmol/L, (522.93 ± 353.66) U/L, respectively, which were significantly higher than (1.04 ± 0.53), (10.37 ± 4.51) μmol/L, (35.73 ± 23.99) U/L, respectively in the T2DM group ( n t = 4.280, 3.780, 5.045, all n P < 0.05). Triacylglycerol level in the ALD + T2DM group was significantly higher than that in the ALD group [(1.69 ± 1.04) mmol/L n vs. (1.28 ± 0.87) mmol/L, n t = 2.523, n P < 0.05). Prothrombin time and lactate dehydrogenase activity in the ALD + T2DM group were (13.13 ± 2.79) s and (226.17 ± 79.93) U/L, respectively, which were significantly higher than (10.41 ± 0.84) s, (172.63 ± 39.34) U/L, respectively in the T2DM group ( n t = 7.715, 4.969, both n P < 0.05). Multivariate Logistic regression analysis showed that prothrombin time, triacylglycerol level, years of drinking, gamma glutamyl transpeptidase activity, and amount of drinking were the main risk factors for ALD combined with T2DM ( n OR = 2.010, 3.270, 1.230, 1.060, 1.006, all n P < 0.05).n Conclusion:Patients with ALD combined with T2DM are prone to metabolic syndrome and lipid disorders, which may aggravate the disease. Prothrombin time, triacylglycerol level, years of drinking play an important role in the development of ALD combined with T2DM.