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目的研究Bcl 2和P5 3蛋白在胃癌发生发展中的作用以及与胃息肉和胃癌的相互关系。方法应用免疫组化法分别检测正常胃粘膜、胃增生性息肉、胃腺瘤性息肉和胃癌中Bcl 2和P5 3蛋白的表达。结果Bcl 2蛋白在正常胃粘膜和胃增生性息肉的表达无显著性差异 (P >0 0 5 ) ,在胃腺瘤性息肉和胃癌的表达与前两者比较有显著性差异 (P <0 0 0 1) ,胃腺瘤性息肉和胃癌之间差异无显著性 (P >0 0 5 )。P5 3蛋白在正常胃粘膜和胃增生性息肉中不表达 ,在胃腺瘤性息肉和胃癌的表达与前两者比较有显著性差异 (P <0 0 5 ) ,而胃腺瘤性息肉和胃癌之间无显著性差异 (P >0 0 5 )。结论检测胃息肉和胃癌中Bcl 2和P5 3蛋白的表达 ,有助于推测胃息肉的生物学行为发展趋势 ,早期诊断胃癌并判断其预后。
Objective To study the role of Bcl-2 and P53 proteins in the development of gastric cancer and their relationship with gastric polyps and gastric cancer. Methods The expressions of Bcl-2 and P53 proteins in normal gastric mucosa, gastric hyperplastic polyps, gastric adenomatous polyps and gastric carcinoma were detected by immunohistochemistry. Results There was no significant difference in the expression of Bcl-2 protein between normal gastric mucosa and gastric hyperplastic polyps (P> 0.05), but significantly different between gastric adenoma and gastric carcinoma (P <0 0) There was no significant difference between gastric adenomatous polyps and gastric carcinoma (P> 0.05). P5 3 protein was not expressed in normal gastric mucosa and gastric hyperplastic polyps. The expression of P53 protein in gastric adenomatous polyp and gastric carcinoma was significantly different from that of the former two (P <0.05), but not in gastric adenomatous polyp and gastric carcinoma There was no significant difference between the two groups (P> 0.05). Conclusion Detection of Bcl-2 and P53 proteins in gastric polyp and gastric cancer is helpful to predict the trend of biological behavior of gastric polyps, to diagnose gastric cancer early and to judge its prognosis.