论文部分内容阅读
癌特异性抗原——促血液凝固癌抗原(CCA1)是作者发现的可直接活化血液凝固第X因子的新丝氨酸蛋白酶。抗CCA-1抗体来自AI18(IgM)细胞培养上清液。抗CEA抗体为抗CEA抗体A5-B7。用免疫组化分析结肠癌原发灶100例、结肠癌肝转移灶7例、腺瘤内癌15例、腺瘤11例。结肠癌中Ⅰ期20例、Ⅱ期21例、Ⅲ期18例、Ⅳ期42例及Ⅴ例17例。并比较CCA-1与CEA在成人及胎儿正常组织分布。 CCA-1在癌肿区各期均呈79.2％～100％阳性,其整体阳性率为92％。中度阳性>75％。正常结肠组织均无CCA-1。CEA据病期不同呈94.1％～100％的阳性率,整体阳性率为98％,但其在72％的正常结肠组织为阳性。癌相邻区正常结肠粘膜可见CEA,但均无CCA-1。CCA-
The cancer-specific antigen, blood procoagulant cancer antigen (CCA1), is a novel serine protease discovered by the authors that directly activates blood coagulation factor X. The anti-CCA-1 antibody was from AI18 (IgM) cell culture supernatant. The anti-CEA antibody is an anti-CEA antibody A5-B7. Immunohistochemistry was used to analyze 100 cases of primary colon cancer, 7 cases of colon metastases, 15 cases of adenomatous carcinoma, and 11 cases of adenoma. There were 20 cases of stage I colon cancer, 21 cases of stage II, 18 cases of stage III, 42 cases of stage IV, and 17 cases of V cases. The distribution of CCA-1 and CEA in normal tissues of adults and fetuses was compared. CCA-1 was 79.2% to 100% positive in each stage of cancerous area, and the overall positive rate was 92%. Moderate positive> 75%. There was no CCA-1 in normal colon tissues. CEA showed a positive rate of 94.1%-100% depending on the stage of illness. The overall positive rate was 98%, but it was positive in 72% of normal colon tissues. CEA was observed in the normal colonic mucosa of the adjoining area but no CCA-1 was found. CCA-