流行性出血热分布于世界25个国家,遍及亚洲、南北美洲、苏联、东欧和北欧以及部分非洲国家。该病流行之广、危害之大目前已被人们公认,因而,对于本病的防治研究是一项非常重要的课题。特别是进行疫苗研制和发病机理的研究,又都急需一种具有肾综合征出血热病人样表现的动物模型。虽然最近国外报道出血热病毒感染乳鼠后能引起发病,但在不同毒株之间发病很不规律。1984年3月份以来,我们用从不同地区出血热患者血液中分离 Epidemic hemorrhagic fever spread in 25 countries in the world, throughout Asia, North and South America, the Soviet Union, Eastern Europe and northern Europe, as well as some African countries. The popularity of the disease, the great harm has now been recognized, therefore, for the prevention and treatment of this disease is a very important issue. In particular, research on vaccine development and pathogenesis has also been an urgent need for an animal model of human-like manifestation of hemorrhagic fever with renal syndrome. Although the recent reports of hemorrhagic fever virus infection in suckling mice can cause disease, but the incidence of different strains is very irregular. Since March 1984, we have isolated blood from patients with hemorrhagic fever in different regions