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为研究食管癌相关基因2(ECRG2)STR多态性与新疆汉族食管癌易感性的关系,在新疆地区进行了一个食管癌研究(食管癌84例,人群对照53例),采用PCR-SSCP技术检测研究对象的ECRG2 STR基因型。结果显示:ECRG2STR呈多态性,可分为3种类型:TCA3/TCA3,TCA4/TCA4,TCA3/TCA4,在有转移的食管癌中分布为67.9%、7.1%、25.0%,在无转移的食管癌中分布为14.3%、44.6%、41.1%,两者相比,有显著差异(χ2=26.18,df=2,P<0.01)。在病例对照研究中,在食管癌中所占比例分别是32.1%、32.1%、35.8%,对照组分别是15.1%、49.1%、35.8%,两组总构成比有显著差异(χ2=6.10,P=0.047)。由此可知ECRG2基因TCA3/TCA3基因型与TCA4/TCA4基因型比较,增加了患食管癌和发生转移的风险。
In order to study the relationship between estrogen-associated gene 2 (ESRG2) STR polymorphisms and susceptibility to esophageal cancer in Han nationality in Xinjiang, an esophageal cancer study was conducted in Xinjiang (84 cases of esophageal cancer and 53 cases of population controls). PCR-SSCP The subject’s ECRG2 STR genotype was tested. The results showed that ECRG2STR was polymorphic and could be divided into three types: TCA3 / TCA3, TCA4 / TCA4 and TCA3 / TCA4. The distribution of ECRG2STR was 67.9%, 7.1% and 25.0% in esophageal cancer with metastasis The distribution of esophageal cancer was 14.3%, 44.6% and 41.1%, respectively. There was significant difference between them (χ2 = 26.18, df = 2, P <0.01). In the case-control study, the proportions in esophageal cancer were 32.1%, 32.1% and 35.8% respectively, while those in control group were 15.1%, 49.1% and 35.8%, respectively. There was significant difference between the two groups (χ2 = 6.10, P = 0.047). This shows that ECRG2 gene TCA3 / TCA3 genotypes and TCA4 / TCA4 genotypes increase the risk of esophageal cancer and metastasis.