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原发性醛固酮增多症(PA)是目前最常见的继发性高血压,且高醛固酮水平是心脏、肾脏、血管等靶器官损害的独立危险因素。随着动态血压监测的广泛应用,发现高血压患者不仅是血压高,血压变异性也大,并且后者与心血管事件发生及心脏、肾脏等靶器官损害关系更为密切。因此,研究PA患者血压变异性对靶器官的损害有重要意义,降低血压变异性对早期预防心血管事件及并发症有广阔的临床应用前景。
Primary aldosteronism (PA) is by far the most common secondary hypertension and high aldosterone levels are independent risk factors for target organ damage such as heart, kidney and blood vessels. With the wide application of ambulatory blood pressure monitoring, it is found that patients with hypertension are not only high in blood pressure and large in variability of blood pressure, but also have a close relationship with cardiovascular events and target organs such as heart and kidney. Therefore, the study of PA blood pressure variability on the target organ damage is important, reduce the variability of blood pressure in the early prevention of cardiovascular events and complications have a broad clinical application prospects.