α-(4-氟苯基)-4-(5-氟-2-嘧啶基)-1-哌嗪丁醇,代号BMY 14802可能是一个副作用比常用药物少的抗精神病药.N-烯丙基降美他佐辛(NAN)在慢性脊髓狗上产生明显的行为效应,这是NAN与σ-阿片受体相互作用的结果.用豚鼠脑匀浆(细胞膜)可以测定〔~3H〕NAN与非阿片受体的结合,后来证明只有(+)-NAN才结合到非阿片受体上.阿朴吗啡的作用与NAN类似,说明这两个药物是通过多巴胺能机理发挥作用的.专一的σ-阿片受体拮抗剂可能为研制新的抗精神病药物提供有效途径.BMY 14802具有阻断条件性逃避反应,阻止阿朴 Alpha-4-fluorophenyl) -4- (5-fluoro-2-pyrimidinyl) -1-piperazine butanol, codenamed BMY 14802, may be an antipsychotic with fewer side effects than commonly used medications. The hypotensive effect of natriamicin (NAN) on chronic spinal cord dogs was observed as a result of the interaction of NAN with the sigma-opioid receptor. [~ 3H] NAN can be measured with guinea pig brain homogenate (cell membrane) The binding of non-opioid receptors proved later that only (+) - NAN binds to non-opioid receptors.Poromorphine acts similarly to NAN, demonstrating that both drugs act through the dopaminergic mechanism.pecific Sigma-opioid receptor antagonists may provide an effective way for the development of new antipsychotic drugs.BMY 14802 has a blocking conditional escaping response,