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目的:观察中药抗感解毒汤对全身炎症反应综合征(SIRS)患儿的临床疗效及对TNF-α、IL-6水平的影响。方法:将60例确诊为SIRS的患儿随机分为治疗组和对照组,所有患儿均常规抗炎、对症治疗,治疗组加服中药抗感解毒汤,疗程结束后观察两组的中医证候疗效及TNF-α、IL-6的水平。结果:治疗组中医证候疗效显效率96.67%,与对照组相比,差异显著(P<0.05);两组治疗后TNF-α、IL-6水平较治疗前均下降明显,但治疗组水平下降更明显,与单纯西药治疗后相比差异显著(P<0.05)。结论:TNF-α、IL-6均参与了SIRS的病理生理过程;中药抗感解毒能够降低炎性TNF-α、IL-6的水平,值得临床推广应用。
Objective: To observe the clinical efficacy of Kang Gan Jie Du Tang in children with systemic inflammatory response syndrome (SIRS) and its effect on the levels of TNF-α and IL-6. Methods: Sixty children diagnosed as SIRS were randomly divided into treatment group and control group. All children were given routine anti-inflammatory and symptomatic treatment. The treatment group was given traditional Chinese medicine Kanggan Jiedu Decoction. After the treatment, the two groups of TCM syndromes Curative effect and the level of TNF-α, IL-6. Results: The effective rate of TCM syndrome in treatment group was 96.67%, which was significantly different from that in control group (P <0.05). The levels of TNF-α and IL-6 in two groups decreased significantly after treatment, but the levels in treatment group Decline more obvious, and Western medicine compared to the significant difference (P <0.05). CONCLUSION: Both TNF-α and IL-6 are involved in the pathophysiological process of SIRS. Anti-detoxification and detoxification can decrease the levels of inflammatory cytokine TNF-α and IL-6, which is worthy of clinical application.