过敏性紫癜(HSP)是儿童时期最常见的全身广泛性小血管炎,其最为严重的并发症为肾脏损害。对于HSP伴肾病综合征表现的患儿,激素的使用能够治疗并缓解肾脏损害,但对于无尿常规异常或仅有血尿的HSP患儿,是否使用激素,一直存在争议。现介绍国内外关于HSP的治疗方案,主张HSP患儿应早期、足量、足疗程使用激素,并适当配合血浆置换。 Henoch-Schonlein purpura (HSP) is the most common systemic small-vessel vasculitis in childhood, and its most serious complication is kidney damage. The use of hormones can treat and relieve kidney damage in children with HSP with nephrotic syndrome, but it remains controversial whether or not hormones are used in children with HSP without urine abnormalities or hematuria alone. Now introduced at home and abroad on the treatment of HSP, HSP advocates should be early, adequate, full course of use of hormones, and with the appropriate plasma exchange.