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目的研究乙醛脱氢酶2(ALDH2)基因多态性与脑梗死患者颈动脉粥样硬化斑块形成及类型的相关性。方法选择2010年1月至2011年6月收治的、定位于颈动脉系统的动脉粥样硬化性脑梗死患者78例,行颈动脉超声检查,根据结果分为无斑块型、稳定斑块型和易损斑块型,以80例健康人为对照组。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测两组ALDH2基因G487A位点的多态性。结果脑梗死组形成斑块的比例明显高于对照组,该组ALDH2基因AA/AG型出现的频率也显著高于对照组。ALDH2基因为AA/AG型的人比GG型形成颈动脉粥样硬化斑块,尤其是易损斑块的比例更高。结论人ALDH2基因G487A位点的多态性与脑梗死患者颈动脉粥样硬化斑块的稳定性相关。
Objective To investigate the association between ALDH2 gene polymorphism and carotid atherosclerosis plaque formation and type in patients with cerebral infarction. Methods From January 2010 to June 2011, 78 patients with atherosclerotic cerebral infarction, located in the carotid system, underwent carotid ultrasonography. According to the results, they were divided into no plaque type and stable plaque type And vulnerable plaque type, with 80 healthy people as control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the polymorphism of G487A locus in ALDH2 gene. Results The percentage of plaque formation in cerebral infarction group was significantly higher than that in control group. The frequency of ALDH2 gene AA / AG type was also significantly higher than that of control group. People with ALDH2 gene type AA / AG had higher rates of carotid atherosclerosis, especially vulnerable plaque, than those with GG type. Conclusion The polymorphism of G487A locus in human ALDH2 gene is associated with the stability of carotid atherosclerotic plaques in patients with cerebral infarction.