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目的观察T2DM患者血清γ-谷氨酰转肽酶(GGT)的变化,探讨GGT与T2DM患者颈动脉粥样硬化(CAS)的关系。方法选择T2DM(T2DM组)患者35例和正常对照者(NC组)40名,分析GGT和CAS的关系。结果T2DM组GGT高于NC组(P<0.05);T2DM组发生CAS 15例,其中9例为双侧;NC组CAS者2例,其中1例为双侧。Logistic回归分析示,年龄、高血糖和GGT是颈动脉斑块的独立预测因素。结论 T2DM患者GGT水平高于正常人群,同时T2DM患者GGT水平升高与颈动脉粥样斑块形成相关。
Objective To observe the changes of serum glutamyl transpeptidase (GGT) in patients with T2DM and to explore the relationship between GGT and carotid atherosclerosis (CAS) in patients with T2DM. Methods Forty-five patients with T2DM (T2DM group) and 40 normal controls (NC group) were selected to analyze the relationship between GGT and CAS. Results The GGT in T2DM group was higher than that in NC group (P <0.05). There were 15 CAS cases in T2DM group, of which 9 cases were bilateral. In CAS group, 2 cases were CAS and 1 case was bilateral. Logistic regression analysis showed that age, hyperglycemia and GGT were independent predictors of carotid plaque. Conclusions The GGT level in patients with T2DM is higher than that in normal people. Meanwhile, the level of GGT in T2DM patients is correlated with the formation of carotid artery atherosclerotic plaque.