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[目的]探讨卵巢上皮癌p27和bcl鄄2的表达及其意义。[方法]应用免疫组化检测100例卵巢上皮癌p27和bcl鄄2蛋白表达,分析其与治疗及预后的关系。[结果]p27和bcl鄄2在恶性卵巢上皮癌组织阳性表达率明显低于卵巢正常组织和良种肿瘤组织(P=0.01,P=0.001)。其表达与卵巢上皮癌分期、分化程度、中位缓解期、2年复发率和总生存时间有关。分期、分化程度、术后残留大小和p27表达是影响预后的重要因素,未发现bcl鄄2的表达与卵巢癌的预后相关。[结论]p27和bcl鄄2的表达与卵巢恶性肿瘤相关,能较好预测近期治疗效果。p27可以作为判定预后的相对独立指标,而bcl鄄2间接影响预后。
[Objective] To investigate the expression of p27 and bcl-2 in epithelial ovarian cancer and its significance. [Method] The expressions of p27 and bcl-2 protein in 100 cases of epithelial ovarian cancer were detected by immunohistochemistry, and their relationship with the treatment and prognosis were analyzed. [Results] The positive expression rate of p27 and bcl-2 in malignant ovarian epithelial carcinoma tissues was significantly lower than that in normal ovarian tissues and seed tissues (P = 0.01, P = 0.001). The expression of epithelial ovarian cancer staging, differentiation, the median remission, 2-year relapse rate and overall survival time. Staging, degree of differentiation, postoperative residual size and expression of p27 are important prognostic factors. No correlation was found between the expression of bcl-2 and the prognosis of ovarian cancer. [Conclusion] The expressions of p27 and bcl-2 are correlated with malignant ovarian tumors and can predict the short-term therapeutic effect better. p27 can be used as a relative independent prognostic indicator, while bcl Juan 2 indirectly affect the prognosis.