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目的:探讨生长抑素受体亚型SSTR2和SSTR3在不同类型、不同部位淋巴瘤中的表达情况并分析其临床意义。方法:采用RT-PCR法检测105例4种不同淋巴瘤石蜡标本中SSTR2和SSTR3的基因表达情况。结果:SSTR2及SSTR3在粘膜相关性淋巴瘤阳性表达率分别为(8/27),(6/27),弥漫大B细胞型淋巴瘤(14/36)(,12/36),NK/T细胞淋巴瘤(9/22),(6/22),伯基特淋巴瘤(6/20),(7/20),SSTR2的总阳性率为(37/105),SSTR3的总阳性率为(31/105)。其中病变位于膈上的SSTR2的总阳性率为(24/105),膈下的总阳性率(14/105),而SSTR3在膈上的总阳性率为(19/105),膈下的为(11/105)。结论:部分淋巴瘤组织中至少表达一种生长抑素受体,且表达率较低,但淋巴瘤是对放射性敏感的肿瘤,低表达的生长抑素受体对淋巴瘤的诊断及靶向治疗方面是否有意义,还需要进一步研究。
Objective: To investigate the expression of somatostatin receptor subtypes SSTR2 and SSTR3 in different types and different parts of lymphoma and to analyze their clinical significance. Methods: RT-PCR was used to detect the gene expression of SSTR2 and SSTR3 in 105 cases of four different lymphoma paraffin specimens. Results: The positive expression rate of SSTR2 and SSTR3 in mucosa-associated lymphoma were (8/27), (6/27), diffuse large B cell lymphoma (14/36) (12/36), NK / T The total positive rate of SSTR2 was (37/105), the positive rate of SSTR3 was (9/22), (6/22), Burkitt’s lymphoma (6/20) (31/105). The total positive rate of SSTR2 located on the diaphragm was (24/105) and the total positive rate of the diaphragm (14/105) while the total positive rate of SSTR3 on the diaphragm was (19/105) (11/105). CONCLUSION: Some lymphoma tissues express at least one somatostatin receptor, and the expression rate is low, but lymphoma is a radiosensitive tumor. The low expression of somatostatin receptor on lymphoma diagnosis and targeted therapy Whether it is meaningful, but also need further study.