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目的:观察丁苯酞对老年高血压患者颈动脉内-中膜厚度(IMT)及超敏C反应蛋白(hsCRP)的影响。方法:选择老年高血压患者60例,随机分为对照组及治疗组各30例,前者常规给予降血压药物及阿司匹林100 mg/d,后者在对照组基础上加丁苯酞20 mg,2次/日,随访6个月。在随访前后测量患者IMT及hsCRP。结果:治疗后治疗组IMT及hsCRP明显低于对照组,差异具有统计学意义(P<0.01)。结论:丁苯酞能抑制IMT增长及炎性反应,可延缓动脉粥样硬化的进展。
Objective: To observe the effect of butylphthalide on carotid intima - media thickness (IMT) and hypersensitive C reactive protein (hsCRP) in elderly patients with hypertension. Methods: Sixty elderly patients with hypertension were randomly divided into control and treatment groups, 30 cases in each group. The former was given antihypertensive drugs and aspirin 100 mg / d, the latter on the basis of the control group, butylphthalide 20 mg, 2 Times / day, followed up for 6 months. Patients’ IMT and hsCRP were measured before and after follow-up. Results: After treatment, the IMT and hsCRP in the treatment group were significantly lower than those in the control group, with statistical significance (P <0.01). CONCLUSION: Butylphthalide can inhibit the growth of IMT and inflammatory reaction, and can delay the progress of atherosclerosis.