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目的:探讨口腔癌及癌前病变组织中MMP-9基因表达的临床意义。方法:应用原位杂交技术检测42例口腔癌,20例癌转移淋巴结,22例癌前病变组织及21例正常口腔黏膜组织中MMP-9的表达,并分析其与临床病理特性的关系。结果:转移淋巴结、口腔癌、癌前病变及正常组织中MMP-9基因阳性表达率分别为100%,73.81%,22.73%,9.52%。结论:MMP-9的过度表达与口腔癌的浸润和淋巴结转移密切相关。
Objective: To investigate the clinical significance of MMP-9 gene expression in oral cancer and precancerous lesions. Methods: The expression of MMP-9 in 42 cases of oral cancer, 20 cases of metastatic lymph nodes, 22 cases of precancerous lesions and 21 cases of normal oral mucosa was detected by in situ hybridization. The relationship between the expression of MMP-9 and clinicopathological features was analyzed. Results: The positive rates of MMP-9 in metastatic lymph nodes, oral cancer, precancerous lesions and normal tissues were 100%, 73.81%, 22.73%, 9.52% respectively. Conclusion: The overexpression of MMP-9 is closely related to the infiltration and lymph node metastasis of oral cancer.