ｂｃｌ-２与肿瘤的发生、发展、治疗等有着密切的关系，乳腺癌也不例外，ｂｃｌ２表达在良性乳腺组织基底层和表皮细胞呈阳性，在乳腺癌中也有５８％的表达，且同雌激素受体和孕激素受体有较大的相关性，可能ｂｃｌ２表达受性激素的影响。ｂｃｌ２能阻止各种刺激引起的凋亡的发生，促进细胞存活，所以ｂｃｌ２的表达能引起癌细胞对化疗药物敏感性差，甚至耐受。此外，ｂｃｌ２还与乳腺癌的预后有一定的关系 Bcl-2 is closely related to tumorigenesis, development, and treatment. Breast cancer is no exception. bcl-2 expression is positive in the basal and epidermal cells of benign breast tissue and is also expressed in 58% of breast cancers. There is a large correlation between estrogen and progesterone receptors, and bcl-2 expression may be affected by sex hormones. Bcl 2 can prevent the occurrence of apoptosis caused by various stimuli and promote cell survival. Therefore, the expression of bcl-2 can cause cancer cells to have poor sensitivity to chemotherapy drugs, and even tolerate them. In addition, bcl 2 has a certain relationship with the prognosis of breast cancer