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目的观察鼻咽癌原发灶标本中乏氧诱导因子-1α(HIF-1α)的表达水平,并判断其在预测鼻咽癌预后中的价值。方法用免疫组化技术检测59例鼻咽癌原发病灶标本中HIF-1α的表达情况。同时随访这些患者的治疗结果。结果HIF-1α的表达位于肿瘤细胞核内,67.8%的标本有HIF-1α阳性表达;HIF-1α阳性表达提示远处转移率高,总生存率和无病生存率低。但对局部区域控制率无影响。结论大部分鼻咽癌患者的原发病灶呈现HIF-1α阳性表达,其表达水平对判断鼻咽癌患者的预后有重要价值。
Objective To observe the expression of hypoxia inducible factor-1α (HIF-1α) in primary nasopharyngeal carcinoma and to evaluate its value in predicting the prognosis of nasopharyngeal carcinoma. Methods Immunohistochemistry was used to detect the expression of HIF-1α in 59 primary nasopharyngeal carcinoma specimens. At the same time, follow-up treatment of these patients results. Results The expression of HIF-1α was located in the nucleus of tumor cells. The positive expression of HIF-1α was found in 67.8% of the samples. The positive expression of HIF-1α was associated with high distant metastasis and low overall survival and disease-free survival. But no effect on the control of the local area. Conclusion Most of the primary NPC patients have HIF-1α positive expression. The expression level of HIF-1α is of great value in judging the prognosis of patients with NPC.