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目的探讨糖链抗原19-9(CA19-9)、糖链抗原242(CA242)、癌胚抗原(CEA)肿瘤标志物在胰腺癌诊断中的联合检测价值。方法选取息县人民医院2009年1月至2012年12月126例胰腺癌患者、63例胆管癌、63例胰腺良性疾病患者,检测其血清内CA19-9、CA242、CEA水平。结果胰腺癌患者CA19-9、CA242、CEA水平显著高于胰腺良性疾病、胆管癌患者(P<0.05),三者联合检测特异性更为明显。结论 CA19-9单项检测能够增加胰腺癌诊断时的敏感性,CA19-9、CA242、CEA联合检测能够提高其特异性,具有较高临床应用价值。
Objective To investigate the combined detection of carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 242 (CA242) and carcinoembryonic antigen (CEA) in the diagnosis of pancreatic cancer. Methods 126 cases of pancreatic cancer, 63 cases of cholangiocarcinoma and 63 cases of pancreatic benign disease were selected from Xiyang People’s Hospital from January 2009 to December 2012. The levels of CA19-9, CA242 and CEA in serum were detected. Results The levels of CA19-9, CA242 and CEA in patients with pancreatic cancer were significantly higher than those in patients with benign pancreatic disease and cholangiocarcinoma (P <0.05). The specificity of combined detection was more obvious. Conclusion Single detection of CA19-9 can increase the sensitivity of diagnosis of pancreatic cancer. Combined detection of CA19-9, CA242 and CEA can improve its specificity and has high clinical value.