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本文对一家系同胞兄妹5人中3人先后不同年龄、不同时间罹患脑脊膜瘤进行了详细的家系调查,对术后仍生存的两例患者进行了细胞遗传学分析,发现患者外周血淋巴细胞的染色体畸变率和脆性部位检出率较正常人有明显增高。总结并讨论了肿瘤与染色体畸变发生的关系。对于家族性脑脊膜瘤的遗传发生机理还需要在分子水平上作进一步研究。
In this paper, a family sibling sibling 5 people 3 people of different ages and at different times have a detailed family survey of meningiomas, two patients still alive after surgery for cytogenetic analysis showed that patients with peripheral blood lymph nodes The chromosome aberration rate and the detection rate of brittle parts of cells were significantly higher than those in normal people. Summarized and discussed the relationship between tumor and chromosomal aberration. The genetic mechanism of familial meningioma needs to be further studied at the molecular level.