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目的:对糖皮质激素治疗原发性肾紫癜进行总结性研究。方法:选择2012年1月-2012年12月入住我院的原发性肾紫癜患者16例。临床症状均为大量肉眼可见的血尿,并伴有血凝块出现。将所有患者按照随机分配原则分为甲泼尼龙组,氢化可的松组,对照组等三个小组。三组患者均使用输血、止血、促凝、抗感染等常规对症治疗,泼尼龙组在常规对症治疗的基础上使用甲泼尼龙+250ml5%C6H12O6溶液静脉滴注;氢化可的松组在输血、止血、促凝、抗感染等常规对症治疗的基础上使用200mg氢化可的松+250ml5%C6H12O6溶液静脉滴注;泼尼龙组与氢化可的松组均待无血尿症状时,改用30mg醋酸泼尼松口服,待病情逐渐稳定后慢慢减量并停止使用药物。结果:甲泼尼龙组与氢化可的松组治愈率达100%,对照组治愈率为0%。结论:使用糖皮质激素治疗原发性肾紫癜效果显著,且无激素不良反应发生,可以广泛推广。
Objective: To study the glucocorticoid treatment of primary renal purpura. Methods: From January 2012 to December 2012, 16 patients with primary renal purpura admitted to our hospital were enrolled. Clinical symptoms are a lot of macroscopic hematuria, accompanied by blood clots appear. According to the principle of random distribution, all patients were divided into three groups: methylprednisolone group, hydrocortisone group and control group. The three groups of patients were given routine symptomatic treatment such as blood transfusion, hemostasis, procoagulant and anti-infective. The prednisolone group was given intravenous infusion of methylprednisolone + 250ml 5% C6H12O6 solution on the basis of conventional symptomatic treatment. In the hydrocortisone group, Hemostatic, procoagulant, anti-infective and other conventional symptomatic treatment based on the use of 200mg hydrocortisone + 250ml5% C6H12O6 solution intravenous infusion; prednisolone group and hydrocortisone group were hematuria without hemorrhage symptoms, use 30mg acetate infusion Nisong oral, until the condition gradually stabilized and then slowly stop using the drug. Results: The cure rate of methylprednisolone group and hydrocortisone group was 100%, while that of the control group was 0%. Conclusion: The treatment of primary renal purpura with glucocorticoid has a significant effect, and no hormone adverse reactions, can be widely promoted.