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目的 研究 p2 7kipl在胃癌组织中的表达和生物学行为及对预后评价的意义。 方法 以免疫组织化学方法检测 92例胃癌组织中 p2 7kipl表达水平。 结果 92例胃癌中 ,p2 7kipl蛋白阳性 39例 (4 2 .4% ) ,其中弱阳性 2 8例 (71.8% ) ,强阳性 11例 (2 8.2 % )。在胃癌组织中 ,p2 7kipl蛋白水平与胃壁浸润深度、TNM分期、病理组织学分级、区域淋巴结转移等均相关。单因素生存分析 ,p2 7kipl高表达组 3,5年生存率分别为 77.1% ,5 7.8% ,明显高于低表达组 33.7% ,2 6 .3% (P=0 .0 0 2 )。Cox回归模型多因素分析显示 ,p2 7kipl是一个独立的预后指标 (P=0 .0 0 0 3)。 结论 p2 7kipl在胃癌中表达降低 ,可作为反映肿瘤恶性表型的指标 ,对胃癌预后判断具有一定的价值
Objective To study the expression of p27kipl in gastric cancer and its biological behavior and prognostic significance. Methods The expression of p27kipl in 92 cases of gastric carcinoma was detected by immunohistochemistry. Results Among the 92 cases of gastric cancer, there were 39 cases (42.4%) positive for p2 7kip1 protein, of which 28 cases were weak positive (71.8%) and 11 cases were strong positive (2 8.2%). In gastric cancer, p2 7kipl protein level and gastric wall depth of invasion, TNM staging, histopathological grading, regional lymph node metastasis are related. Univariate survival analysis showed that the 3-year and 5-year survival rates of high expression group of p27kipl were 77.1% and 7.8%, respectively, which were significantly higher than those of low expression group (33.7%, 26.3%, P = 0.002). Cox regression model multivariate analysis showed that p2 7kipl was an independent prognostic indicator (P = 0.00003). Conclusion The decreased expression of p27kipl in gastric cancer can be used as an indicator of the malignant phenotype of the tumor and has certain value in the prognosis of gastric cancer