论文部分内容阅读
卡铂是第二代铂类抗肿瘤药物,经临床前及临床研究该药抗瘤谱广,其作用机理与顺铂相似,且尚未发现类似顺铂对肾和高频区听力的损伤,消化道反应也低于顺铂,其剂量限制性毒性仍为可逆性骨髓抑制。此药不必水化,在很多常见肿瘤的联合化疗方案中有取代顺铂的趋向。我院1994年3月至1999年3月应用国产卡铂(齐鲁制药厂)治疗晚期肺癌43例,现报道如下。材料与方法一般情况:男34例,女9例。年龄22～74岁,平均60.5岁。43例经病理或细胞学证实,因病变广泛不宜手术或术后复发,转移的晚期肺癌病人。其中小细胞肺
Carboplatin is the second generation of platinum anti-tumor drugs, preclinical and clinical studies of the drug anti-tumor spectrum wide, its mechanism of action and similar cisplatin, and has not found similar to cisplatin on the kidneys and high-frequency hearing damage, digestion Road response is also lower than that of cisplatin, its dose-limiting toxicity is still reversible myelosuppression. This medicine does not have to be hydrated and has the tendency of displacing cisplatin in the combination chemotherapy regimen of many common tumors. Our hospital from March 1994 to March 1999 application of domestic carboplatin (Qilu Pharmaceutical Factory) treatment of advanced lung cancer in 43 cases, are reported below. Materials and Methods General situation: 34 males and 9 females. Aged 22 to 74 years old, average 60.5 years old. 43 cases confirmed by pathology or cytology, due to extensive lesions should not be surgery or postoperative recurrence and metastasis of advanced lung cancer patients. Among them are small cell lungs