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目的:探讨康艾注射液联合奥沙利铂、亚叶酸钙、氟尿嘧啶化疗治疗晚期胃癌的疗效。方法:晚期胃癌患者76例随机分为2组,对照组36例给予奥沙利铂100 mg/m2,静脉滴注,第1天;亚叶酸钙200 mg/m2,静脉滴注,第2~6天;氟尿嘧啶350 mg/m2,静脉滴注,第2~6天。治疗组40例在对照组治疗基础上给予康艾注射液60 mL,静脉滴注,第1~15天。2组均21 d为1个疗程,治疗2个疗程后比较2组近期疗效、不良反应和生活质量。结果:治疗组有效率46.0%,对照组有效率39.5%,2组比较差异无统计学意义(P>0.05)。治疗组白细胞减少,恶心、呕吐,周围神经毒性发生率均低于对照组(P<0.05),生活质量优于对照组(P<0.05)。结论:康艾注射液联合奥沙利铂、亚叶酸钙、氟尿嘧啶化疗可减轻晚期胃癌患者化疗不良反应,提高生活质量。
Objective: To investigate the curative effect of Kangai injection combined with oxaliplatin, leucovorin and fluorouracil chemotherapy in advanced gastric cancer. Methods: 76 patients with advanced gastric cancer were randomly divided into two groups, the control group, 36 patients were given oxaliplatin 100 mg / m2, intravenous infusion, on the first day; leucovorin 200 mg / m2, intravenous drip, 6 days; fluorouracil 350 mg / m2, intravenous drip, 2 to 6 days. Treatment group, 40 cases in the control group given Kang Ai injection 60 mL, intravenous drip, the first to 15 days. The two groups were 21 days for a course of treatment, after 2 courses of treatment compared two groups of short-term efficacy, adverse reactions and quality of life. Results: The effective rate was 46.0% in the treatment group and 39.5% in the control group. There was no significant difference between the two groups (P> 0.05). The incidences of leukopenia, nausea, vomiting and peripheral neurotoxicity in the treatment group were lower than those in the control group (P <0.05), and the quality of life was better than that in the control group (P <0.05). Conclusion: Kangai injection combined with oxaliplatin, leucovorin and fluorouracil chemotherapy can reduce adverse reactions of chemotherapy in patients with advanced gastric cancer and improve quality of life.