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沉默信息调节因子(Sirtuins)是一种依赖于烟酰胺腺嘌呤二核苷酸的Ⅲ类组蛋白去乙酰化酶，可调节多种酶活性并参与生物过程。近年研究发现，Sirtuins家族成员与支气管哮喘的发生密切相关。该文就Sirtuins家族在支气管哮喘发病过程中的作用进行综述，为Sirtuins家族作为支气管哮喘的潜在治疗靶点提供依据。“,”Silent information adjustment factor(Sirtuins)are Ⅲ class histone deacetylase on the nicotinamide adenine dinucleotide(NADn +), and regulate various enzyme activities and biological processes.Recent studies have found that members of the Sirtuins family are closely related to the occurrence of bronchial asthma.This review summarizes the role of the Sirtuins family in the pathogenesis of bronchial asthma and provides a basis for the Sirtuins family as a potential therapeutic target for bronchial asthma.n