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【目的】探讨蛋白质对早产儿早期免疫功能的影响。【方法】根据出生2周内摄入蛋白质量的不同对43例早产儿进行分组,平均摄入蛋白质≥3 g/(kg.d)为高蛋白组,而摄入蛋白质<3 g/(kg.d)为一般蛋白质组。比较两组早产儿3日龄、第二周IgA、IgG、IgM、C3、C4、CD3、CD4、CD8、CD4/CD8、血尿素氮(BUN)、肌酐(SCr)的水平。【结果】出生满2周,高蛋白质组IgM水平较治疗前升高,与一般蛋白质组差异有统计学意义(P<0.05);两组IgG水平较治疗前下降(P<0.01),两组T细胞亚群CD3、CD4、CD4/CD8比值均有明显增高,CD8值下降,治疗前后比较有差异高度有统计学意义(P<0.01);治疗后高蛋白质组与一般蛋白质组CD3、CD4、CD4/CD8水平比较差异有统计学意义(P<0.05);CD8值两组无统计学意义(P>0.05);【结论】提高早产儿早期营养中蛋白质的量[≥3 g/(kg.d)],能改善其免疫功能。
【Objective】 To investigate the effect of protein on early immune function in premature infants. 【Method】 According to the quantity of protein intake during the first 2 weeks of birth, 43 cases of preterm infants were divided into three groups. Average protein intake (≥3 g / (kg · d)) was high protein group, while intake of protein <3 g / (kg .d) for the general proteome. The levels of IgA, IgG, IgM, C3, C4, CD3, CD4, CD8, CD4 / CD8, blood urea nitrogen (BUN) and creatinine (SCr) 【Results】 IgM levels in high-proteome group were significantly higher than those in the normal control group at 2 weeks after birth (P <0.05). IgG levels in both groups were significantly lower than those before treatment (P <0.01) The ratio of CD3, CD4 and CD4 / CD8 of T cell subsets were significantly increased and the CD8 value was decreased before and after treatment. There was a significant difference between before and after treatment (P <0.01) CD4 / CD8 levels were significantly different (P <0.05); CD8 between the two groups was not statistically significant (P> 0.05); 【Conclusion】 Increasing the amount of protein in preterm infants [≥3 g / (kg. d)], can improve their immune function.