慢性疲劳综合征（CFS）以持久、无用性疲劳、卧床休息不能缓解及无任何躯体原因可解释为特点。第一代抗抑郁药因其副作用而使CFS病人无法耐受。Lynch等报告使用镇静作用较弱、自主神经系统副作用较少的抗抑郁新药氟西汀（fluoxetine）可有效治疗CFS。但尚无对照性研究，故本文 Chronic fatigue syndrome (CFS) is characterized by long-lasting, useless fatigue, inability to rest in bed, and without any physical cause. The first generation of antidepressants made CFS patients intolerant because of their side effects. Lynch et al reported the use of fluoxetine, a new antidepressant drug with weaker sedation and less autonomic nervous system side effects, to treat CFS. However, there is no comparative study, so this article