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目的:观察CD3AK细胞肝瘤内局部注射结合肝动脉插管化疗栓塞术(TACE)治疗中、晚期原发性肝癌的近期观察疗效。方法:对20例中、晚期原发性肝癌的外周血行CD3AK细胞培养后肝瘤内局部注射并结合肝动脉插管化疗栓塞术,并与同期24例中、晚期原发性肝癌单纯行肝动脉插管化疗栓塞术(TACE)相对照。结果:完全缓解(CR)1例,部分缓解(PR)15例,有效率RR(CR+PR)80.0%,患者的细胞免疫功能明显提高(P<0.01)。结论:CD3AK细胞局部注射结合化疗治疗中、晚期恶性肿瘤的近期疗效增加(P<0.05),患者的细胞免疫功能明显提高,值得临床推广和应用。
Objective: To observe the short-term effect of local injection combined with transcatheter arterial chemoembolization (TACE) of CD3AK cells in the treatment of middle and advanced primary liver cancer. Methods: Peripheral blood samples from 20 patients with advanced primary hepatocellular carcinoma were injected locally with hepatic artery in combination with chemoembolization after CD3AK cells were cultured. In the same period, 24 patients with primary hepatocellular carcinoma were treated with hepatic artery Intubation chemoembolization (TACE) contrast. Results: Complete remission (CR) in 1 case, partial remission (PR) in 15 cases and effective RR (CR + PR) in 80.0% patients were significantly improved (P <0.01). Conclusion: The recent curative effect of CD3AK cells by local injection combined with chemotherapy in the treatment of middle and advanced malignant tumors was increased (P <0.05). The cellular immune function of patients with CD3AK cells was significantly improved, which is worthy of clinical promotion and application.