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目的探讨注射用薏苡仁油联合肠内营养治疗老年癌症恶液质的疗效及毒副作用。方法将70例老年癌症恶液质患者分为两组,A组用注射用薏苡仁油联合肠内营养(36例),B组单用肠内营养(34例),通过比较两组的生存质量、体重变化、免疫功能及疼痛缓解率来评估疗效。结果治疗前两组体重无统计学差异(P>0.05),治疗后A组[(59.0±8.8)kgvs.(60.4±8.8)kg,P<0.01]和B组[(57.6±8.2)kgvs.(58.0±8.3)kg,P<0.01]体重均增加,A组增加幅度高于B组[(1.4±0.7)kgvs.(0.4±0.4)kg,P<0.01]。A、B组卡氏评分增加≥10分的比例分别为(77.8%vs.35.3%,P<0.01),疼痛缓解率(72.2%vs.47.1%,P<0.05)。只有A组治疗后NK细胞比例升高(3.8±3.9)%(P<0.05)。两组的不良反应无明显差异。结论与单用肠内营养相比,注射用薏苡仁油联合肠内营养能更好地改善老年癌症恶液质患者的生活质量、增进食欲、增加体重、缓解疼痛并提高免疫功能。
Objective To investigate the curative effect and toxic side effects of injecting coix seed oil and enteral nutrition in treating elderly patients with cancer cachexia. Methods Seventy patients with malignant tumor of the elderly were divided into two groups: group A was treated with coix seed oil for injection (36 cases), group B was enteral nutrition alone (34 cases), and the survival of the two groups was compared Quality, weight changes, immune function and pain relief rate to assess the efficacy. Results There was no significant difference in body weight between the two groups before treatment (P> 0.05). After treatment, the mean arterial pressure in the group A was (59.0 ± 8.8) kg vs (60.4 ± 8.8) kg, P <0.01 and [57.6 ± 8.2] kgvs (58.0 ± 8.3) kg, P <0.01]. The increase in group A was higher than that in group B [(1.4 ± 0.7) kg vs (0.4 ± 0.4) kg, P <0.01]. The rates of increase of cardiothrix scores in group A and group B were respectively ≥10 (77.8% vs.35.3%, P <0.01), pain relief rate was 72.2% vs 47.1% (P <0.05). Only group A showed a significant increase in the percentage of NK cells (3.8 ± 3.9)% (P <0.05). There was no significant difference in adverse reactions between the two groups. Conclusion Compared with enteral nutrition alone, co-injection of coix seed oil and enteral nutrition can improve the quality of life, increase appetite, increase body weight, relieve pain and improve immune function in elderly patients with cancer cachexia.