本文介绍α_2肾上腺素能受体激动药右旋美托咪啶(DMED)的药理作用和临床试用近况。DMED为高效、高选择性的α_2受体激动药,具有抑制交感神经、镇静、催眠、镇痛和麻醉作用,不良反应少且轻。临床试用结果表明,此药可使麻醉药用量明显减少,抑制气管插管时的应激反应,降低限内压,减少麻醉恢复期激动和恶心,并可用于术后镇痛,是很有前途的麻醉辅助药。 This article describes the pharmacological effects and clinical trials of α 2 adrenergic receptor agonist dexmedetomidine (DMED). DMED is an efficient and highly selective alpha-2 agonist with sympathetic, sedative, hypnotic, analgesic and anesthetic effects with less and less adverse reactions. Clinical trial results show that this drug can significantly reduce the amount of anesthetics, inhibition of endotracheal intubation during stress response, reduce the pressure limit, reduce anesthesia concussion and nausea, and can be used for postoperative analgesia, is very Promising anesthetic adjuvant.