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Objective: The aim of our study was to investigate Bcl-2 antanogene-1 (Bag-1) expressions in gastric cancer and evaluate their clinical significance. Methods: Bag-1 expressions were studied by the immunohistochemical streptavidinperosidase (S-P) method in 62 samples of gastric cancer tissues, 11 normal gastric tissues, and their clinical significance was analyzed. Results: The positive rate of Bag-1 expression in the gastric carcinoma tissues was 41.94% (26/62), while it was 9.09% (1/11) in the normal gastric tissues (P = 0.046). Though Bag-1 was positively related to the tumour pathological grade, lymph node metastasis and prognosis (P < 0.05), it was not related to the sex, age, location, tumour diameter, depth of invasion (P > 0.05). Conclusion: There are over expression of Bag-1 gene protein in gastric cancer, it is significance in prognosis of gastric cancer.