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:目的 用正交试验研究平脂胶囊制备工艺 .方法 选择三因素三水平正交试验 ,以出膏率和芍药甙含量为指标 ,用HPL C法测定煎煮稠膏中芍药甙含量 .结果 9份试验平均出干膏率 2 3.3% ,芍药甙平均含量 0 .6 3% ,平均综合分 6 8.8,煎煮时间对工艺影响显著 (P<0 .0 5 ) ,最佳制备工艺是煎煮 2次 ,每次 2 h,加水 5倍量 .结论 双指标多因素正交试验优化的中药复方制剂制备工艺经 3批扩大 1 1 4 .8倍中试 ,重现性好 ,结果稳定 ,从而确保质量
:Objective To study the preparation process of Pingzhi capsule by orthogonal test.Methods Three factors and three levels of orthogonal test were selected, and the content of peony glycosides in boiling thick paste was determined by HPL C. The average test results showed that the dry paste rate was 3.3%, the average content of paeoniflorin was 0.63%, the average composite score was 68.8, and the boiling time had a significant effect on the process (P<0.05). The best preparation process was boiling. 2 times, 2 hours each time, add 5 times of water. Conclusions The preparation process of the traditional Chinese medicine compound preparation optimized by the double index multifactor orthogonal experiment has been expanded by 1 batch of 1 4 4 .8 times, with good reproducibility and stable results. quality assurance