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目的:研究AST及AST-Ⅳ不同剂量对无水乙醇致大鼠急性胃黏膜损伤的保护作用。方法:将SD大鼠随机分为模型组,AST大、中、小剂量组,AST-Ⅳ大、中、小剂量组,西药阳性对照组,分别给予溶剂注射液、AST及AST-Ⅳ不同剂量注射液、西米替丁注射液腹腔注射。于给药1次1.5、1.25h后及给药4次于末次给药1.5、1.25h后,用无水乙醇诱导大鼠急性胃黏膜损伤,观察各组胃黏膜损伤情况。结果:给药1次及给药4次中除AST-Ⅳ小剂量组外,其余各组均有不同程度的降低损伤分数和光镜下损伤指数的作用,且AST各剂量组优于AST-Ⅳ各剂量组,AST大剂量组明显优于其他剂量组,与西药阳性对照组作用相当;给药1次与给药4次相同的剂量组相比,无显著性差异;AST各组给药1次作用优于AST-Ⅳ各组给药4次。结论:AST及AST-Ⅳ对大鼠无水乙醇所致的急性胃黏膜损伤有保护作用,AST的作用明显优于AST-Ⅳ,且随剂量的增加,AST的优越性更加明显,AST大剂量的保护作用已经接近阳性对照药西米替丁的水平;给药1次及给药4次,不存在药效叠加的现象;AST单次给药的保护作用优于AST-Ⅳ多次给药。
Objective: To study the protective effects of different doses of AST and AST-Ⅳ on acute gastric mucosal injury induced by ethanol in rats. Methods: SD rats were randomly divided into model group, AST large, medium and small dose groups, AST-Ⅳ large, medium and small dose groups, Western medicine positive control group were given solvent injection, AST and AST- Injection, cimetidine injection intraperitoneal injection. After administration of 1.5,1.25 hours and administration of 4 times 1.5,1.25 hours after the last administration, acute gastric mucosal injury was induced by ethanol in rats, and the gastric mucosal damage in each group was observed. Results: In addition to the AST-Ⅳ low-dose group and the other four groups, the injury scores and the damage index under light microscope were all decreased to a lesser extent, and AST-Ⅳ Each dose group, AST high-dose group was significantly better than the other dose group, and western medicine positive control group has the same effect; once administered and administered 4 times the same dose group, no significant difference; AST each group administered 1 Sub-effect is better than AST-IV each group administered 4 times. CONCLUSION: AST and AST-Ⅳ have protective effects on acute gastric mucosal injury induced by ethanol in rats, and the effect of AST is obviously better than that of AST-Ⅳ. AST is more obvious with the increase of dosage, Of the protective effect has been close to the positive control drug cimetidine level; administration and administration of 4 times, there is no effect of drug overlay; AST single-dose protection is superior to multiple administration of AST-IV .